Beta-NGF (Animal Free)

CAT: 0209-100-447-AFSize: 100 µgDry Ice: NoHazardous: No

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CAT#:0209-100-447-AFSize:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

Synonyms

NGF-β, beta-Nerve Growth Factor

NCBI Gene ID

4803

UniProt

P01138

Accession Number

NP_002497

Accession Number mRNA

NM_002506

Chromosomal Location

1p13.2

Reactivity

Human

Cross Reactivity

Human

Sequence

SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA

Endotoxin

< 0.01 ng/µg of protein (< 0.1 EU/µg)

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Bioactivity

Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Length

120

Form

Lyophilized

Molecular Weight

27 kDa

Host or Source

E. coli

UniProtKB · P01138

Beta-nerve growth factor

NGF_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P01138
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NGF
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: Beta-NGF
EC number: —
Processing: Precursor
Secondary accessions: A1A4E5, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Disease

Disease variantNeurodegenerationNeuropathy

Cellular component

EndosomeSecreted

Molecular function

Growth factorMetalloenzyme inhibitorMetalloprotease inhibitorProtease inhibitor

Ligand

Lipid-binding

Domain

Signal

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Alternative Products

Catalog	Name
MBS692750-01	Human beta-NGF(Animal Free)
HY-P700018AF-01	Animal-Free beta-NGF, Human (His)
HY-P700162AF-01	Animal-Free beta-NGF, Mouse (His)
GTR18895274-01	Recombinant beta-NGF (Nerve growth factor-beta), Mouse, Animal-Free
GTR18895460-01	Recombinant beta-NGF (Nerve growth factor-beta), Human, Animal-Free
C-CYP290-20ug	Recombinant Mouse β-NGF / Beta-Nerve Growth Factor, Animal Free & Carrier Free
C-CYP356-100ug	Recombinant Human β-NGF / Beta-Nerve Growth Factor, Animal Free & Carrier Free
208603-01	Beta-NGF, Recombinant, Human, Animal Free (beta-Nerve Growth Factor) discontinued
PRP1143-01	Mouse β-NGF protein, His tag (Animal-Free)
PRP1061-01	Human β-NGF protein, His tag (Animal-Free)