MIP-3 beta (CCL19)

• Description:

  MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19

• NCBI Gene ID:

  6363

• UniProt:

  Q99731

• Accession Number:

  NP_006265

• Accession Number mRNA:

  NM_006274

• Chromosomal Location:

  9p13

• Reactivity:

  Human

• Cross Reactivity:

  Monkey, Mouse, Human, Leech, Bacteria

• Sequence:

  GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human T cells using a concentration of 10.0-50.0 ng/ml.

• Length:

  77

• Form:

  Lyophilized

• Molecular Weight:

  8.8 kDa

• Host or Source:

  E. coli