MIG (CXCL9)

• Description:

  MIG, a CXC chemokine, is produced by IFN stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor. MIG selectively chemoattracts Th1 lymphocytes, and also exerts other activities including inhibition of tumor growth, angiogenesis, and inhibition of colony formation of hematopoietic progenitors. Human MIG is active on murine cells. Recombinant human MIG is an 11.7 kDa protein containing 103 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

• Synonyms:

  CMK; MIG; Humig; SCYB9; crg-10

• NCBI Gene ID:

  4283

• UniProt:

  Q07325

• Accession Number:

  NP_002407.1

• Accession Number mRNA:

  NM_002416.1

• Chromosomal Location:

  4q21

• Reactivity:

  Human

• Cross Reactivity:

  Human, Mouse

• Sequence:

  TPVVRKGRCS CISTNQGTIH LQSLKDLKQF APSPSCEKIE IIATLKNGVQ TCLNPDSADV KELIKKWEKQ VSQKKKQKNG KKHQKKKVLK VRKSQRSRQK KTT

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human peripheral blood T lymphocytes using a concentration range of 10.0-100.0 ng/ml.

• Length:

  103

• Form:

  Lyophilized

• Molecular Weight:

  11.7 kDa

• Host or Source:

  E. coli