MICB

CAT: 0209-101-M570Size: 50 µgDry Ice: NoHazardous: No

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CAT#:0209-101-M570Size:50 µg

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Description

MICB (MHC class I chainrelated gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulinlike domains, but have no capacity to bind peptide or interact with β2microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ αβ T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down regulates NKG2D surface expression on effector cells resulting in the impairment of ant-itumor immune response .

Synonyms

MICB; PERB11.2

NCBI Gene ID

4277

UniProt

Q29980

Accession Number

NP_005922.2

Accession Number mRNA

NM_005931.3

Chromosomal Location

6p21.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human MICB

Clone

(#3C37)

Applications

WB, FC

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

UniProtKB · Q29980

MHC class I polypeptide-related sequence B

MICB_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q29980
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: MICB
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: MIC-B
EC number: —
Processing: Precursor
Secondary accessions: A2AC57, A6NP85, B0UZ10, B2RAK2, O14499, O14500, O19798, O19799, O19800, O19801, O19802, O19803, O78099, O78100, O78101, O78102, O78103, O78104, P79525, P79541, Q5GR31, Q5GR37, Q5GR41, Q5GR42, Q5GR43, Q5GR44, Q5GR46, Q5GR48, Q5RIY6, Q5SSK1, Q5ST25, Q7JK51, Q7YQ89, Q861E6, Q9MY18, Q9MY19, Q9MY20, Q9UBH4, Q9UBZ8, Q9UEJ0, X6R344

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityCytolysisHost-virus interactionImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainSignalTransmembraneTransmembrane helix

Related Products

Catalog	Name
101-M569	MICA
100-338-L500	GDF-15/MIC-1
100-338-L1000	GDF-15/MIC-1
100-338-L100	GDF-15/MIC-1
100-338S	GDF-15/MIC-1
100-338-L250	GDF-15/MIC-1
100-338	GDF-15/MIC-1

Alternative Products

Catalog	Name
216823	MICB
048541	MICB (U.Washington patent MICB) discontinued
GTR18156382-01	MICB Antibody
MBS8576982-01	MICA + MICB
TS422315P5	MICB CytoSection
OM305233-01	MICB Human
A3092-1mg	Anti-MICB
OPPA01281-2UG	MICB Protein