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Mer

CAT: 0209-103-M188Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M188Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anti-coagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.
Synonyms
Mertk; Eyk; Mer; Nyk; nmf12
NCBI Gene ID
17289
UniProt
Q12866
Accession Number
NP_006334.2
Accession Number mRNA
NM_006343.2
Chromosomal Location
2 F1; 2
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant Mouse Mer extracellular domain
Clone
(#3D07)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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