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Lyve-1

CAT: 0209-103-M130Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M130Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Synonyms
Lyve1; Xlkd1; Lyve-1; Crsbp-1; 1200012G08Rik
NCBI Gene ID
114332
UniProt
Q8BHC0
Accession Number
NP_444477
Accession Number mRNA
NM_053247
Chromosomal Location
7; 7F2
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant LYVE-1
Clone
(#4D17)
Applications
WB, IHC (F)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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Alternative Products

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GWB-7B1284LYVE-1
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RLT-102-PA50AGLYVE-1 (human), pAb
BS65744-01LYVE-1 Polyclonal Antibody
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