LDH (Plasmodium falciparum)

CAT: 0209-400-003Size: 25 µgDry Ice: NoHazardous: No

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CAT#:0209-400-003Size:25 µg

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Description

Malaria is one of the most widespread infectious diseases affecting some 500 million people with an enormous cost in human suffering and economic hardship. Effective treatment of the disease is increasingly compromised by rising resistance of malaria parasites to currently available anti-malarials. The parasites are homolactate fermenters and rely on glycolysis for energy generation since the parasites appear to lack a functional citric acid cycle. The NAD+ consumed during glycolysis is reduced to NADH by lactate which, in turn, is oxidized to pyruvate. This reaction is catalyzed by lactate dehydrogenase (LDH) . It has been demonstrated that inhibitors of this enzyme have parasiticidal activity. Since LDH from the malaria parasite Plasmodium falciparum (PfLDH) has notable structural and kinetic differences from human LDHs, the enzyme appears to be an attractive target for novel anti-malarial therapeutics. The parasite, P. falciparum, is the most lethal of malarial plasmodia being responsible for the cerebral form of the disease; consequently it has been the major focus of initial biochemical and genomic investigation. On the other hand, the parasite P. vivax is of great importance as it is the most widespread and common of the malarial plasmodia and, therefore, is responsible for the greatest burden of disease.

Synonyms

Lactate dehydrogenase

UniProt

Q71T02

Accession Number

AAG14292.1

Accession Number mRNA

AF251291.1

Cross Reactivity

Human

Sequence

PLAMAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA

Applications

Standard for ELISA

Purity

> 85% by SDS-PAGE & Coomassie stain

Length

319

Form

Liquid

Buffer

50 mM Tris, 250 mM NaCl, 1 mM EDTA

Molecular Weight

35 kDa

Storage Conditions

According to the available data the liquid protein stored at 4-8°C is stable at least for about 10 months.

Host or Source

Insect cells

UniProtKB · Q71T02

L-lactate dehydrogenase

Q71T02_PLAFA · Plasmodium falciparum

View on UniProt ↗

Primary accession: Q71T02
Review status: UniProtKB unreviewed (TrEMBL)
Gene: LDH-P
Protein existence: 1: Evidence at protein level
Organism: Plasmodium falciparum (malaria parasite P. falciparum)
Taxonomy ID: 5833
Alternative names: —
EC number: 1.1.1.27
Processing: —
Secondary accessions: —

Protein keywords

Technical term

3D-structure

Ligand

CalciumMetal-bindingNADPyruvate

Molecular function

Oxidoreductase

Related Products

Catalog	Name
400-005	LDH (Plasmodium vivax)

Alternative Products

Catalog	Name
MBS320430-01	Plasmodium Falciparum
10-P09B	Plasmodium falciparum antibody
P4256-68A	Plasmodium falciparum (Malaria)
MBS310527-01	MAb to Plasmodium falciparum
OT055	Plasmodium Falciparum/Plasmodium Vivax Antigen