Kremen-1

• Description:

  Kremen (Kringle-containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Two related members, Kremen-1 and -2, have been identified. Kremens bind a subset of the secreted Dickkopf (Dkk) proteins with high affinity. The canonical Wnt signaling pathway receptor complex composed of Wnt, the seven-transmembrane domain receptor Frizzled, and the receptor-related protein 5/6 (LRP5/6) coreceptor, is modulated by Kremens and Dkk proteins.

• Synonyms:

  Kremen1; Krm1; Kremen; AV002070

• NCBI Gene ID:

  84035

• UniProt:

  Q99N43

• Accession Number:

  NP_115772.2

• Accession Number mRNA:

  NM_032396.3

• Chromosomal Location:

  11 A1; 11

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Mouse recombinant EC domain of Kremen-1

• Clone:

  (#6K45)

• Applications:

  WB

• Purification Method:

  Protein A/G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2