Jagged-1

• Description:

  JAG1 is a protein associated with Alagille syndrome. JAG1 has also been designated as CD339 (cluster of differentiation 339) . The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

• Synonyms:

  JAG1; AGS; AHD; AWS; HJ1; CD339; JAGL1

• NCBI Gene ID:

  182

• UniProt:

  P78504

• Accession Number:

  NP_000205.1

• Accession Number mRNA:

  NM_000214.2

• Chromosomal Location:

  20p12.1-p11.23

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human Jagged-1

• Clone:

  (#4A24)

• Applications:

  WB, FC

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG2