I-TAC (CXCL11) (Animal Free)

• Description:

  I-TAC is a 'non-ELR' CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, ormonocytes. Recombinant Human I-TAC (CXCL11) is an 8.3 kDa protein containing 73 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.

• Synonyms:

  CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B

• NCBI Gene ID:

  6373

• UniProt:

  O14625

• Accession Number:

  NP_005400.1

• Accession Number mRNA:

  NM_005409.4

• Chromosomal Location:

  4q21.2

• Reactivity:

  Human

• Cross Reactivity:

  Hamster, Mouse, Rabbit, Human, Monkey

• Sequence:

  FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 98% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by its ability to chemoattract human T-cells activated with IL-2.

• Length:

  73

• Form:

  Lyophilized

• Molecular Weight:

  8.3 kDa

• Host or Source:

  E. coli