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IL-22

CAT: 0209-M10-072SSize: 2 µgDry Ice: NoHazardous: No
CAT#: M10-072SSize: 2 µg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 32-34 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.
Synonyms
IL22; IL-22; Iltif; IL-22a; ILTIFa
NCBI Gene ID
50929
UniProt
Q9JJY9
Accession Number
NP_058667.1
Accession Number mRNA
NM_016971
Chromosomal Location
10 D2; 10 67.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay#1: Determined by its ability to activate STAT following receptor ligand interaction. Assay#2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells) . The expected ED50 for this effect is 1.0-2.0 ng/ml.
Length
146
Form
Lyophilized
Molecular Weight
33.4 kDa
Host or Source
E. coli

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