Rat Anti-Mouse IL-17 Monoclonal Antibody
CAT:
209-103-M411
Size:
100 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Rat Anti-Mouse IL-17 Monoclonal Antibody
- Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
- Synonyms: Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A
- CAS Number: 9007-83-4
- NCBI Gene ID: 16171
- UniProt: Q62386
- Accession Number: NP_034682.1
- Accession Number mRNA: NM_010552.3
- Gene Location: 1; 1 A
- Host: Rat
- Origin Species: Mouse
- Species Reactivity: Mouse
- Target Antigen: Mouse Recombinant protein of IL-17
- Isotype: IgG2
- Clone: (#4H48)
- Validated Applications: WB, N
- Purification Method: Protein A/G chromatography
- Form: Lyophilized
- Buffer: PBS
- Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- Shipping Conditions: Room Temperature
- Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.