Mouse Anti-Human IL-17 Monoclonal Antibody
CAT:
209-101-M483
Size:
100 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Mouse Anti-Human IL-17 Monoclonal Antibody
- Description: The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
- Synonyms: IL17A; IL17; CTLA8; IL-17; IL-17A
- CAS Number: 9007-83-4
- NCBI Gene ID: 3605
- UniProt: Q16552
- Accession Number: NP_002181.1
- Accession Number mRNA: NM_002190.2
- Gene Location: 6p12
- Host: Mouse
- Origin Species: Human
- Species Reactivity: Human
- Target Antigen: Recombinant Human IL-17
- Isotype: IgG1
- Clone: (#9J17)
- Validated Applications: WB
- Purification Method: Protein G chromatography
- Form: Lyophilized
- Buffer: PBS
- Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- Shipping Conditions: Room Temperature
- Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.