IL-13 (109aa) Recombinant Protein
CAT:
209-R20-031
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IL-13 (109aa) Recombinant Protein
- Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.
- Synonyms: Il13
- CAS Number: 9000-83-3
- NCBI Gene ID: 116553
- UniProt: P42203
- Accession Number: NP_446280.1
- Accession Number mRNA: NM_053828
- Gene Location: 10q22
- Host: E. coli
- Origin Species: Rat
- Species Reactivity: Human, Rat
- Sequence: VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSMVWSVDL TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH
- Detection Range: The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is < 5 ng/ml, corresponding to a specific activity of > 2 x 105 units/mg.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 109
- Form: Lyophilized
- Molecular Weight: 11.9 kDa
- Shipping Conditions: Room Temperature