IL-13 Recombinant Protein

IL-13 Recombinant Protein

• Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.
• Synonyms: Il13; Il-13
• CAS Number: 9000-83-3
• NCBI Gene ID: 16163
• UniProt: P20109
• Accession Number: NP_032381.1
• Accession Number mRNA: NM_008355
• Gene Location: 11 B1.3; 11 29.0 cM
• Host: E. coli
• Origin Species: Mouse
• Species Reactivity: Human, Mouse
• Sequence: MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
• Detection Range: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 105 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 111
• Form: Lyophilized
• Buffer: 10 mM sodium citrate pH 4.0
• Molecular Weight: 12.3 kDa
• Shipping Conditions: Room Temperature