IL-5 Recombinant Protein

IL-5 Recombinant Protein

• Description: IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant human IL-5 is a 26.0 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.
• Synonyms: IL5; EDF; TRF; IL-5
• CAS Number: 9000-83-3
• NCBI Gene ID: 3567
• UniProt: P05113
• Accession Number: NP_000840.1
• Accession Number mRNA: NM_000879
• Gene Location: 5q31.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Mouse, Human, Guinea Pig
• Sequence: MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES
• Detection Range: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 0.15 ng/ml, corresponding to a specific activity of ≥ 6.6 x 106 units/mg.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 116
• Form: Lyophilized
• Molecular Weight: 26 kDa
• Shipping Conditions: Room Temperature