IGF-BP2 Recombinant Protein

IGF-BP2 Recombinant Protein

• Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
• Synonyms: IGFBP2; IBP2; IGF-BP53
• CAS Number: 9000-83-3
• NCBI Gene ID: 3485
• UniProt: P18065
• Accession Number: NP_000588.2
• Accession Number mRNA: NM_000597
• Gene Location: 2q33-q34
• Host: Insect Cells
• Origin Species: Human
• Species Reactivity: Mouse
• Sequence: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ
• Detection Range: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 289
• Form: Lyophilized
• Molecular Weight: 31.5 kDa
• Shipping Conditions: Room Temperature