IFN omega

• Description:

  IFN-ω is a type I interferon, which can be induced by virus-infected leukocytes. Members of the type I interferon family, which includes IFN-alpha, IFN-ß, and IFN-ω, signal through IFNAR-1/IFNAR-2 receptor complex, and exert antiviral and antiproliferative activities. IFN-ω exhibits about 75% sequence homology with IFN-alpha, and contains two conserved disulfide bonds, which are necessary for full biological activity. Recombinant Human IFN-ω is a 19.9 kDa protein consisting of 172 amino acid residues.

• Synonyms:

  IFNW1; Interferon omega

• NCBI Gene ID:

  3467

• UniProt:

  P05000

• Accession Number:

  NP_002168.1

• Accession Number mRNA:

  NM_002177

• Chromosomal Location:

  9p22

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  CDLPQNHGLL SRNTLVLLHQ MRRISPFLCL KDRRDFRFPQ EMVKGSQLQK AHVMSVLHEM LQQIFSLFHT ERSSAAWNMT LLDQLHTGLH QQLQHLETCL LQVVGEGESA GAISSPALTL RRYFQGIRVY LKEKKYSDCA WEVVRMEIMK SLFLSTNMQE RLRSKDRDLG SS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 108 units/mg.

• Length:

  172

• Form:

  Lyophilized

• Molecular Weight:

  19.9 kDa

• Host or Source:

  E. coli