IFN beta (Animal Free)

• Description:

  Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues.

• Synonyms:

  IFNB1; IFB; IFF; IFNB

• NCBI Gene ID:

  3456

• UniProt:

  P01574

• Accession Number:

  NP_002167.1

• Accession Number mRNA:

  NM_002176

• Chromosomal Location:

  9p21

• Reactivity:

  Human

• Cross Reactivity:

  Human, Mouse

• Sequence:

  MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 95% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.25 ng/ml, corresponding to a specific activity of ≥ 4 x 106 units/mg.

• Length:

  166

• Form:

  Lyophilized

• Molecular Weight:

  20 kDa

• Host or Source:

  E. coli