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HGF

CAT: 0209-102-PA62SSize: 100 µgDry Ice: NoHazardous: No
CAT#:0209-102-PA62SSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.
Synonyms
HGF; SF; HGFB; HPTA; F-TCF; DFNB39
NCBI Gene ID
3082
UniProt
P14210
Accession Number
NP_000592
Accession Number mRNA
NM_000601
Chromosomal Location
7q21.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human HGF (RT #300-011)
Clone
Rabbit IgG
Applications
WB
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: Use 1-5 µg/ml
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

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