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HB-EGF

CAT: 0209-100-185Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-100-185Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.
Synonyms
HBEGF; DTR; DTS; DTSF; HEGFL
NCBI Gene ID
1839
UniProt
Q99075
Accession Number
NP_001936.1
Accession Number mRNA
NM_001945
Chromosomal Location
5q23
Reactivity
Human
Cross Reactivity
Human, Mouse, Rat
Sequence
DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPSC ICHPGYHGER CHGLSL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Length
86
Form
Lyophilized
Molecular Weight
9.7 kDa
Host or Source
E. coli

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