GRO-gamma (CXCL3)

• Description :

  All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant human GRO-γ is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

• Synonyms :

  CXCL3; GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b

• NCBI Gene ID :

  2921

• UniProt :

  P19876

• Accession Number :

  NP_002081.2

• Accession Number mRNA :

  NM_002090.2

• Chromosomal Location :

  4q21

• Reactivity :

  Human

• Cross Reactivity :

  Hamster, Human, Mouse

• Sequence :

  ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml.

• Length :

  73

• Form :

  Lyophilized

• Molecular Weight :

  7.9 kDa

• Host or Source :

  E. coli