GRO/KC (CXCL1)

• Description:

  All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

• Synonyms:

  Cxcl1; Gro1; CINC-1

• NCBI Gene ID:

  81503

• UniProt:

  P14095

• Accession Number:

  NP_110472.1

• Accession Number mRNA:

  NM_030845.1

• Chromosomal Location:

  14p22

• Reactivity:

  Rat

• Cross Reactivity:

  Rat, Mouse

• Sequence:

  APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract rat neutrophils using a concentration range of 10.0-100.0 ng/ml.

• Length:

  72

• Form:

  Lyophilized

• Molecular Weight:

  7.8 kDa

• Host or Source:

  E. coli