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Gremlin-1

CAT: 0209-M30-025Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-M30-025Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gremlin was identified in a Xenopus expression cloning screen as a dorsalizing factor that can induce a secondary axis. A rat homolog, called Drm, was identified as a cDNA that was down regulated in v Mos transfected cells. Gremlin/Drm belongs to the DAN family of secreted glycoproteins that are BMP antagonists. Other members of the family include: Cerberus, Dante, PRDC, Caronte and DAN. DAN family members share a cysteine-rich domain that is structurally related to the cysteine-knot motif found in TGFβ superfamily ligands. In vitro, Gremlin/Drm binds BMP4 and BMP2 indicating that it might interfere with BMP signaling. Gremlin/Drm acts as a BMP2/ 4 antagonist in a variety of tissues and developmental processes including: Xenopus animal cap explants, chick limb bud outgrowth and chondrogenesis, murine lung branching morphogenesis, and osteogenic differentiation of mouse myoblasts and bone marrow stromal cells. In addition, expression of Gremlin/Drm has been shown to be down-regulated in a wide range of human cancer cell lines. Mouse, human, chick and Xenopus homologs of Gremlin share over 80% amino acid identity. It is likely that various DAN family members and other BMP antagonists including Noggin, Chordin, Follistatin and TSG can selectively antagonize the activities of different subsets of TGFβ superfamily ligands.
Synonyms
Grem1; ld; Drm; Cktsf1b1
NCBI Gene ID
23892
UniProt
O70326
Accession Number
NP_035954.1
Accession Number mRNA
NM_011824.4
Chromosomal Location
2 E4; 2 64.5 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
MKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
Assay Protocol
Mouse Grem-1 should be reconstituted in 50 mM acetic acid or water to a concentration of 0.1 mg/ml. This solution can be diluted in water or other buffer solutions or stored at -20°C.
Purity
> 95% by SDS-PAGE
Bioactivity
Data not available.
Length
161
Form
Lyophilized
Buffer
50 mM acetic acid
Reconstitution
50 mM acetic acid
Molecular Weight
20.7 kDa
Storage Conditions
The lyophilized mouse Grem-1, though stable at room temperature, is best stored desiccated below 0°C
Host or Source
E. coli
N Terminal Sequence
MKKKGSQGAIPP

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