GLP-1

• Description :

  GLP-1 is a proglucagon-derived peptide hormone secreted primarily by intestinal L cells during feeding. Its major physiological function is stimulation of pancreatic β-cells to release appropriate amounts of insulin after glucose absorption. Other biological actions exhibited by GLP-1 include suppression of plasma glucagons levels, inhibition of gastric motility, and promotion of satiety. The secretion of GLP-1 from intestinal L cells is stimulated by nutrients, hormones, and neural inputs. On the other hand, insulin has been reported to inhibit GLP-1 release, indicating that a feedback loop mechanism regulates GLP-1 secretion. In addition to being the precursor of GLP-1, proglucagon, whose primary structure is highly conserved in mammalian species, is also the precursor for other members of the glucagon family of peptide hormones including glicentin-related pancreatic peptide (GRPP), glucagons, and GLP-2. Recombinant human GLP-1 is a 3.3 kDa consisting of 31 amino acid residues.

• Synonyms :

  GLP1; GLP2; GRPP

• NCBI Gene ID :

  2641

• UniProt :

  P01275

• Accession Number :

  NP_002045.1

• Accession Number mRNA :

  NM_002054.4

• Chromosomal Location :

  2q36-q37

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  HAEGTFTSDV SSYLEGQAAK EFIAWLVKGR G

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Data not available.

• Length :

  31

• Form :

  Lyophilized

• Molecular Weight :

  3.3 kDa

• Host or Source :

  E. coli