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GLP-1

CAT: 0209-100-339SSize: 200 µgDry Ice: NoHazardous: No
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CAT#:0209-100-339SSize:200 µg
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Description
GLP-1 is a proglucagon-derived peptide hormone secreted primarily by intestinal L cells during feeding. Its major physiological function is stimulation of pancreatic β-cells to release appropriate amounts of insulin after glucose absorption. Other biological actions exhibited by GLP-1 include suppression of plasma glucagons levels, inhibition of gastric motility, and promotion of satiety. The secretion of GLP-1 from intestinal L cells is stimulated by nutrients, hormones, and neural inputs. On the other hand, insulin has been reported to inhibit GLP-1 release, indicating that a feedback loop mechanism regulates GLP-1 secretion. In addition to being the precursor of GLP-1, proglucagon, whose primary structure is highly conserved in mammalian species, is also the precursor for other members of the glucagon family of peptide hormones including glicentin-related pancreatic peptide (GRPP), glucagons, and GLP-2. Recombinant human GLP-1 is a 3.3 kDa consisting of 31 amino acid residues.
Synonyms
GLP1; GLP2; GRPP
NCBI Gene ID
2641
UniProt
P01275
Accession Number
NP_002045.1
Accession Number mRNA
NM_002054.4
Chromosomal Location
2q36-q37
Reactivity
Human
Cross Reactivity
Human
Sequence
HAEGTFTSDV SSYLEGQAAK EFIAWLVKGR G
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Data not available.
Length
31
Form
Lyophilized
Molecular Weight
3.3 kDa
Host or Source
E. coli

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