FRP-1, soluble Recombinant Protein
CAT:
209-S01-070S
Size:
5 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FRP-1, soluble Recombinant Protein
- Description: Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.
- Synonyms: soluble Frizzled Related Protein-1, Secreted Apoptosis Related protein-2, SARP-2
- CAS Number: 9000-83-3
- NCBI Gene ID: 6422
- UniProt: Q8N474
- Accession Number: NP_003003.3
- Accession Number mRNA: NM_003012.4
- Gene Location: 8p11.21
- Host: HeLa Cells
- Origin Species: Human
- Species Reactivity: Mouse
- Sequence: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK
- Detection Range: Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3–0.5 μg/ml.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 97% by SDS-PAGE & HPLC analyses
- Length: 283
- Form: Lyophilized
- Molecular Weight: 32.5 kDa
- Shipping Conditions: Room Temperature