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Flt-3 Ligand

CAT: 0209-R20-076Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0209-R20-076Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Flt3‐Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3‐Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3‐Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3‐Ligand exerts no activity on mast cells. Multiple isoforms of Flt3‐Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.) . The membrane‐bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Rat Flt3‐Ligand is a soluble 18.3 kDa protein consisting of 162 amino acid residues.
Synonyms
Fms‐related tyrosine kinase 3 ligand, Flt3L
NCBI Gene ID
140635
UniProt
Reviewed Data Unavailable
Accession Number
NP_001292868.1
Accession Number mRNA
NM_001305939.1
Chromosomal Location
12p11
Reactivity
Rat
Cross Reactivity
Rat
Sequence
TPDCYFSHSP ISSNFHMRIS ELTDYLLKDY PVTVAINLQD EKHCKALWSL FLAHRWIEQL KTVAGSKMQK LLEDVNTEIH FVTSCTFQPL PECLRFVQTN ISHLLQDTCS QLLALKPCIG KACQNFSRCL EVQCQPDSST LLPPESPGAL GATELPKPLP RQ
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of human AML5 cells.
Length
162
Form
Lyophilized
Molecular Weight
18.3 kDa
Host or Source
E. coli

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