Flt-3 Ligand

• Description :

  Flt3-ligand (flk2-ligand) stimulates the proliferation and colony formation of certain BM precursor cells including CD34+ cells. Flt3-ligand produced in E. coli is a soluble non-glycosylated 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.

• Synonyms :

  FLT3; FLK2; STK1; CD135; FLK-2

• NCBI Gene ID :

  2323

• UniProt :

  P49771

• Accession Number :

  NP_001450.2

• Accession Number mRNA :

  NM_001459.3

• Chromosomal Location :

  19q13.3

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & Coomassie stain

• Bioactivity :

  Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 0,5 – 1 ng/mL.

• Length :

  155

• Form :

  Lyophilized

• Molecular Weight :

  17.6 kDa

• Host or Source :

  E. coli