FGFR-3

• Description:

  Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding. Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N terminal signal peptide, three immunoglobulin (Ig) like domains, an acid box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine kinase domain.

• Synonyms:

  Fibroblast growth factor receptor 3, FGFR-3, Heparin-binding growth factor receptor, CD333

• NCBI Gene ID:

  14184

• UniProt:

  Q61851

• Accession Number:

  NP_001156687.1

• Accession Number mRNA:

  NM_001359036.1

• Reactivity:

  Anti-Mouse

• Target Antigen:

  Mouse recombinant protein FGF R3

• Clone:

  (#7M13)

• Applications:

  N/B

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2