Exodus-2 (CCL21)

• Description:

  Exodus-2 is a CC chemokine that can signal through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant murine Exodus-2 is a 12.0 kDa protein containing 110 amino acid residues.

• Synonyms:

  Ccl21a; ALP; SLC; plt; CKb9; Tca4; 6Ckine; Scya21; 6CKBAC2; SCYA21a; Scya21b; AW987545

• NCBI Gene ID:

  18829

• UniProt:

  P84444

• Accession Number:

  NP_035254

• Accession Number mRNA:

  NM_011124

• Chromosomal Location:

  4 A5; 4 13.3 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Monkey, Leech, Rat

• Sequence:

  SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FLPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract total murine T cell population using a concentration range of 10.0-100.0 ng/ml.

• Length:

  110

• Form:

  Lyophilized

• Molecular Weight:

  12.0 kDa

• Host or Source:

  E. coli