Eotaxin-3 (CCL26)

• Description:

  Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha

• NCBI Gene ID:

  10344

• UniProt:

  Q9Y258

• Accession Number:

  NP_006063

• Accession Number mRNA:

  NM_006072

• Chromosomal Location:

  7q11.23

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human CCR3/HEK 293 cells. The maximum activity was achieved at 2 µg/ml.

• Length:

  71

• Form:

  Lyophilized

• Molecular Weight:

  8.4 kDa

• Host or Source:

  E. coli