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Eotaxin-2

CAT: 0209-101-M01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M01Size:500 µg
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Description
Eotaxin2, also named MPIF-2 and Ckβ6, is a CC chemokine that is designated CCL24. Eotaxin2 cDNA encodes a 10.5 kDa, 119 amino acid residue precursor protein with a 26 aa residue signal peptide that is cleaved to generate a mature protein predicted to contain 93 amino acid residues with an N-glycosylation site. C-terminally truncated variants with 78, 73, 75 and 76 residues have also been described. Eotaxin 2 shares 40%, 42% and 39% amino acid sequence identity with other CC chemokines CCL7/MCP3, CCL3/MIP1α, and CCL11/Eotaxin, respectively. Eotaxin2 mRNA is weakly expressed in activated monocytes and T lymphocytes. Recombinant Eotaxin2 induces chemotaxis of eosinophils, basophils, and resting T lymphocytes, but not monocytes or activated T lymphocytes. Eotaxin2 also suppresses colony formation by high proliferative multipotential hematopoietic progenitors. On eosinophils, the effects of Eotaxin2, Eotaxin and CCL13/MCP4 are mediated by the receptor CCR3.
Synonyms
CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24
NCBI Gene ID
6369
UniProt
O00175
Accession Number
NP_002982.2
Accession Number mRNA
NM_002991
Chromosomal Location
7q11.23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human Eotaxin-2 (CCL24)
Applications
ELISA, WB, IHC (P)
Purification Method
Protein A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Mouse
Isotype
IgG1, kappa

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