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Endocan/ESM-1

CAT: 0209-102-PA44SSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-PA44SSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endocan, also known as endothelial cell specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is upregulated by TNFα, IL1β, or lipopolysaccharide and downregulated by IFNγ. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte functionassociated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM-1 and reducing LFA1-mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
Synonyms
Endocan, ESM1
NCBI Gene ID
11082
UniProt
Q9NQ30
Accession Number
NP_008967.1
Accession Number mRNA
NM_007036.4
Chromosomal Location
5q11.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human ESM-1 (RT #300-062)
Clone
Rabbit IgG
Applications
WB, IF
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: Use 1-5 µg/ml
Form
Lyophilized
Buffer
0.5X PBS, pH 7.2
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

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Alternative Products

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YP-W11097-01Human Endocan; ESM-1 (Endocan; ESM-1) ELISA Kit
YP-W34984-01Rat Endocan; ESM-1 (Endocan; ESM-1) ELISA Kit
YP-W21598-01Mouse Endocan; ESM-1 (Endocan; ESM-1) ELISA Kit
IT-600-004p-01Human Endocan/ESM-1
MBS691809-01Mouse Endocan/ESM-1
OM641627Human Endocan/ESM-1 (ESM-1) ELISA Kit
MBS3809499-01Rat Endocan/ESM-1 ELISA Kit
E22-HC022.96Human Endocan/ESM-1 ELISA kit
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