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E-Cadherin

CAT: 0209-103-M523Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M523Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E-Cadherin/Cadherin1, also known as Uvomorulin in the mouse and rat, is a 120 kDa member of the Cadherin family of cell surface glycoproteins that mediate cell adhesion. Mouse ECadherin shares 92% and 81% amino acid sequence identity with the rat and human proteins, respectively. It is a single-pass transmembrane protein that mediates calcium-dependent epithelial cell adhesion. E-Cadherin has five extracellular EC domains that form homophilic cis-clusters between adjacent epithelial cells and trans-clusters within the same cell. E-Cadherin clusters are critical components of adherens junctions between epithelial cells and act in the formation and maintenance of the epithelial cell barrier.
Synonyms
Cadherin-1; ARC-1, Epithelial cadherin (E-cadherin), Uvomorulin
NCBI Gene ID
12550
UniProt
P09803
Accession Number
NP_033994.1.
Accession Number mRNA
NM_009864.3
Reactivity
Anti-Mouse
Target Antigen
Mouse recombinant protein E-cadherin
Clone
(#6N32)
Applications
E
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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