E-Cadherin

CAT: 0209-101-M132Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M132Size:50 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Epithelial (E) Cadherin (E-CAD), also known as Cadherin1, cell-CAM120/ 80 in the human, uvomorulin in the mouse, Arc1 in the dog, and LCAM in the chicken, is a member of the Cadherin family of cell adhesion molecules (gene name CDH1) . Cadherins are calcium-dependent transmembrane proteins which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, α, β, and γ (plakoglobin) . This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a singlepass-transmembrane domain, and a short carboxyterminal cytoplasmic domain responsible for interacting with the catenins. E-Cadherin contains five extracellular calciumbinding domains of approx. 110 amino acids each (amino acids 155-697) .
Synonyms
CDH1; UVO; CDHE; ECAD; LCAM; Arc-1; CD324
NCBI Gene ID
999
UniProt
P12830
Accession Number
NP_004351.1
Accession Number mRNA
NM_004360.3
Chromosomal Location
16q22.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human E-Cadherin protein
Clone
(#21E9)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

Related Products

CatalogName
101-M99VE-Cadherin
103-M449P-Cadherin
101-M601P-Cadherin
101-M240Cadherin-17
101-M151Cadherin-6 (KCAD)
100-410-L100E-Selectin
100-410-L1000E-Selectin
100-410SE-Selectin
300-044VEGF-E
100-410E-Selectin

Alternative Products

CatalogName
168932Cadherin E (E-Cadherin, Cadherin-1)
GWB-F0A37FCadherin-E/E-Cadherin, Antibody
216167Cadherin E (E-Cadherin, CDH1)
168937Cadherin E (E-Cadherin, Cadherin-1) discontinued
CAU36946-01E-cadherin (E-cadherin) Monoclonal Antibody
CAU30862-01E-cadherin (E-cadherin) Polyclonal Antibody
MBS8566084-01E-Cadherin
MBS8533805-01E Cadherin

Popular Products