Dkk-1

• Description :

  DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.

• Synonyms :

  Dickkopf-related protein-1, Dickkopf-1, SK

• NCBI Gene ID :

  22943

• UniProt :

  O94907

• Accession Number :

  NP_036374.1

• Accession Number mRNA :

  NM_012242.2

• Chromosomal Location :

  10q11.2

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Label :

  His-Tag

• Sequence :

  TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRLEHHHH HH

• Purity :

  95% by SDS-PAGE & visualized Coomassie stain

• Length :

  242

• Form :

  Lyophilized from PBS

• Buffer :

  PBS

• Reconstitution :

  Water

• Molecular Weight :

  26.0 kDa

• Host or Source :

  E. coli

• N Terminal Sequence :

  TNLSV