RegisterLogin

Dkk-1

CAT: 0209-200-013SSize: 5 µgDry Ice: NoHazardous: No
CAT#:0209-200-013SSize:5 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 fused to a C terminal His-tag derived from E. coli is a 26 kDa protein containing 235 amino-acid residues.
Synonyms
Dickkopf-related protein-1, Dickkopf-1, SK
NCBI Gene ID
22943
UniProt
O94907
Accession Number
NP_036374.1
Accession Number mRNA
NM_012242.2
Chromosomal Location
10q11.2
Reactivity
Human
Cross Reactivity
Human
Label
His-Tag
Sequence
TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRLEHHHH HH
Purity
95% by SDS-PAGE & visualized Coomassie stain
Length
242
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Molecular Weight
26.0 kDa
Host or Source
E. coli
N Terminal Sequence
TNLSV

Related Products

CatalogName
100-436-L100Dkk-2
100-408SDkk-3
200-014SDkk-2
102-PA34SDkk-2
103-M372Dkk-3
100-436-L250Dkk-2
100-436-L500Dkk-2
100-436-L1000Dkk-2
100-408-L500Dkk-3
100-436SDkk-2

Alternative Products

CatalogName
E52Y00701DKK-1
535570-01Dkk-1 discontinued
Z03289-1DKK-1, Mouse
Z03462-10DKK-1, Human
F51803-0.4MLDKK-1 Antibody
MBS692271-01Human Dkk-1
MBS8593224-01Dkk-1 Polyclonal Antibody
MBS9524813-01Dkk-1 Monoclonal Antibody
4010-DK-010Recombinant Rat Dkk-1
MBS566756-01Dkk-1 (mouse), (recombinant)

Popular Products