Dectin-1

CAT: 0209-103-M370Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-103-M370Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dectin1, also known as CLEC7A and the β-glucan receptor, is a 43 kDa type II transmembrane C-type lectin that functions in the innate immune response to fungal pathogens. Although Dectin1 resembles other CLEC molecules structurally, it binds ligands in a calciumindependent manner. Mature mouse Dectin1 is a 244 amino acid (aa) glycoprotein that consists of a short ITAMcontaining cytoplasmic tail, a transmembrane segment, and a stalk and carbohydrate recognition domain (CRD) in the extracellular domain. The CRD of mouse Dectin1 shares 61%, 60%, and 87% aa sequence identity with that of bovine, human, and rat Dectin1, respectively. It shares 25% 34% aa sequence identity with the CRD of other subgroup members CLEC1, CLEC2, CLEC9A, CLEC12B, LOX1, and MICL. Mouse Dectin1 is alternately spliced, generating a variant that lacks the stalk region. Mouse Dectin1 is expressed on monocytes, macrophages, and neutrophils, and on some populations of dendritic cells and T cells. It is upregulated on macrophages by GM-CSF, IL4, or IL13 and downregulated by dexamethasone, IL10, or LPS. The CRD selectively binds βglucan polymers, a major component of yeast and mycobacterial cell walls. Yeast βglucan is accessible to Dectin1 only at sites of cell budding, and Dectin1 does not recognize the filamentous form of yeast. Dectin1 mediates the phagocytosis of zymosan particles and intact yeast. It colocalizes with TLR2 in the presence of zymosan, and the two receptors cooperate in ligand recognition and the propagation of proinflammatory signaling. Dectin1 interaction with the tetraspanin CD37 increases its stability on the cell membrane and inhibits ligandinduced signaling. Genetic knockout of Dectin1 in mice increases their susceptibility to pathogenic infection.
Synonyms
Clec7a; BGR; beta-GR; Clecsf12
NCBI Gene ID
56644
UniProt
Q6QLQ4
Accession Number
NP_064392.2
Accession Number mRNA
NM_020008.2
Chromosomal Location
6 F3; 6
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant protein Dectin-1
Clone
(#9A44)
Applications
WB
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2b

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