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C-Reactive Protein (CRP)

CAT: 0209-101-M279Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M279Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-Reactive Protein (CRP) is a member of the Pentraxin family of proteins that are characterized by a cyclic, non-covalent, pentameric structure. IL-6, IL-1 beta, and glucocorticoids induce hepatic C-Reactive Protein synthesis and release. In humans, C-Reactive Protein is a major acute phase protein, increasing by 1,000-fold within 24 to 48 hours of infection, inflammation or tissue damage. C-Reactive Protein exhibits calcium-dependent binding of its principle ligand, phosphocholine, a constituent of bacterial and fungal cell walls. Upon ligand binding, C-Reactive Protein initiates the activation of the complement cascade and binds Fc gamma RI (CD64) and Fc gamma RIIA (CD32a) on phagocytes to activate phagocytic responses. In mouse, C-Reactive Protein is expressed at very low levels and is not an acute phase reactant.
Synonyms
CRP; PTX1
NCBI Gene ID
1401
UniProt
P02741
Accession Number
NP_000558.2
Accession Number mRNA
NM_000567.2
Chromosomal Location
1q21-q23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant C-Reactive Protein (CRP)
Clone
(#5M33)
Applications
Capture Ab
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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