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CRP

CAT: 0209-102-P104Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P104Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-Reactive Protein (CRP) is a member of the Pentraxin family of proteins that are characterized by a cyclic, non-covalent, pentameric structure. IL-6, IL-1 beta, and glucocorticoids induce hepatic C-Reactive Protein synthesis and release. In humans, C-Reactive Protein is a major acute phase protein, increasing by 1,000-fold within 24 to 48 hours of infection, inflammation or tissue damage. C-Reactive Protein exhibits calcium-dependent binding of its principle ligand, phosphocholine, a constituent of bacterial and fungal cell walls. Upon ligand binding, C-Reactive Protein initiates the activation of the complement cascade and binds Fc gamma RI (CD64) and Fc gamma RIIA (CD32a) on phagocytes to activate phagocytic responses. In mouse, C-Reactive Protein is expressed at very low levels and is not an acute phase reactant.
Synonyms
CRP; PTX1
NCBI Gene ID
1401
UniProt
P02741
Accession Number
NP_000558.2
Accession Number mRNA
NM_000567.2
Chromosomal Location
1q21-q23
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
E.coli-derived, 23.2 kDa Recombinant Human CRP
Clone
Rabbit IgG
Applications
WB, ELISA
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
WB: 0.1-0.2 μg/ml
Form
Lyophilized
Reconstitution
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit
Isotype
Rabbit IgG

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