CRP

• Description:

  C-Reactive Protein (CRP) is a member of the Pentraxin family of proteins that are characterized by a cyclic, non-covalent, pentameric structure. IL-6, IL-1 beta, and glucocorticoids induce hepatic C-Reactive Protein synthesis and release. In humans, C-Reactive Protein is a major acute phase protein, increasing by 1,000-fold within 24 to 48 hours of infection, inflammation or tissue damage. C-Reactive Protein exhibits calcium-dependent binding of its principle ligand, phosphocholine, a constituent of bacterial and fungal cell walls. Upon ligand binding, C-Reactive Protein initiates the activation of the complement cascade and binds Fc gamma RI (CD64) and Fc gamma RIIA (CD32a) on phagocytes to activate phagocytic responses. In mouse, C-Reactive Protein is expressed at very low levels and is not an acute phase reactant.

• Synonyms:

  CRP; PTX1

• NCBI Gene ID:

  1401

• UniProt:

  P02741

• Accession Number:

  NP_000558.2

• Accession Number mRNA:

  NM_000567.2

• Chromosomal Location:

  1q21-q23

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  E.coli-derived, 23.2 kDa Recombinant Human CRP

• Clone:

  Rabbit IgG

• Applications:

  WB, ELISA

• Purification Method:

  Antigen-affinity purified

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Bioactivity:

  WB: 0.1-0.2 μg/ml

• Form:

  Lyophilized

• Reconstitution:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Storage Conditions:

  The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

• Host or Source:

  Rabbit

• Isotype:

  Rabbit IgG