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Convertase-9

CAT: 0209-103-M520Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M520Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PCSK9 (proprotein convertase subtilisin kexin 9), also known as NARC1, is a member of the proteinase K subfamily of subtilisin-related serine endoproteases. It is highly expressed in the liver, intestine, and kidney and plays an important role in regulating LDL R expression and circulating cholesterol levels. PCSK9 is synthesized as precursor protein that is autocatalytically cleaved in the endoplasmic reticulum to generate a 14 kDa prodomain and a 60 kDa catalytic domain. Within the secretion pathway, the prodomain remains associated with and functions as a chaperone for the catalytic domain. Mouse PCSK9 shares 78% and 93% amino acid identity with human and rat PCSK9, respectively. PCSK9 plays a key role in the regulation of cholesterol metabolism by binding to hepatic LDL R, LRP1, VLDL R, and Apolipoprotein E R2 and promoting their lysosomal degradation instead of recycling to the plasma membrane.
Synonyms
Proprotein convertase subtilisin/kexin type 9, Neural apoptosis-regulated convertase 1 (NARC-1), Proprotein convertase 9 (PC9), Subtilisin/kexin-like protease PC9
NCBI Gene ID
100102
UniProt
Q80W65
Accession Number
NM_705793.1
Accession Number mRNA
NM_153565.2
Reactivity
Anti-Mouse
Target Antigen
Recombinant Mouse Proprotein Convertase-9
Clone
(#42Q2)
Applications
WB, IP
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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Alternative Products

CatalogName
MBS692586-01Convertase-9
MBS8532923-01PCSK9/Proprotein Convertase 9
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299223Proprotein Convertase 9 (PC9, Neural Apoptosis Regulated Convertase 1, NARC1)
MBS9147663-01Proprotein Convertase 9 (PCSK9) Rabbit mAb
AP87035Proprotein convertase subtilisin/kexin type 9
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