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CD40

CAT: 0209-103-M142Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M142Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD40 ligand (CD40L), also known as CD154, TNFSF5, TRAP or gp39, is a 260 amino acid type II transmembrane glycoprotein belonging to the TNF family. Murine CD40L consists of a 22 aa cytoplasmic domain, a 24 aa transmembrane domain, and 214 aa extracellular domain bearing a single glycosylation site. CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including NK cells, mast cells, basophils and eosinophils. Murine CD40L shares 78% amino acid sequence identity with human CD40L. Native bioactive soluble CD40L exists. Soluble human trimeric CD40L secreted by stimulated T cells has been shown to be generated by proteolysis in the microsomes. Both membrane bound and soluble CD40L induce similar effects on B cells.
Synonyms
Cd40lg; IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5
NCBI Gene ID
21947
UniProt
P27548
Accession Number
NP_035746.2
Accession Number mRNA
NM_011616.2
Chromosomal Location
X A5; X 18.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse Th1 cells
Clone
(#MAB0712)
Applications
IHC, FC
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS (sterile)
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Hamster
Isotype
IgG2

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