CD3e

• Description:

  The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women

• Synonyms:

  T-cell surface antigen T3/Leu-4 epsilon chain

• NCBI Gene ID:

  12501

• UniProt:

  P22646

• Accession Number:

  NP_031674.1

• Accession Number mRNA:

  NM_007648.4

• Reactivity:

  Anti-Mouse

• Target Antigen:

  Recombinant mouse CD3e

• Clone:

  (#1T29)

• Applications:

  FC, IP

• Host or Source:

  Hamster

• Isotype:

  IgG