CCM-3

CAT: 0209-300-056Size: 20 µgDry Ice: NoHazardous: No
CAT#:0209-300-056Size:20 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011) . The CCM-3 is fused to a N-terminal His-tag (6x His) .
Synonyms
PDCD10; CCM3; TFAR15; programmed cell death 10
NCBI Gene ID
11235
UniProt
Q9BUL8
Accession Number
NP_009148
Accession Number mRNA
NM_007217
Chromosomal Location
3q26.1
Reactivity
Human
Cross Reactivity
Human
Label
His-Tag
Sequence
MGSSHHHHHHSSGLVPRGSMRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFVSANRLIHQTNLILQTFKTVA
Assay Protocol
The lyophilized CCM3 is soluble in water and most aqueous buffers and should be reconstituted in water or PBS.
Purity
> 95% by SDS-PAGE
Bioactivity
Data not available.
Length
231
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
26.7 kDa
Storage Conditions
Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted CCM-3 should be stored in working aliquots at -20°C.
Host or Source
E. coli

Related Products

CatalogName
102-PA26CCM-2
300-055CCM-2
102-PA25CCM-1
102-PA26SCCM-2
300-054CCM-1
102-PA25SCCM-1
100-370-L1000PlGF-3
100-356-L250Relaxin-3
100-290-L1000TFF-3
100-360-L200TLR-3

Alternative Products

CatalogName
MBS691618-01Human CCM-3
MF-0114284-01β-CCM
102-PA27Rabbit Anti-Human CCM-3
ABC-TC0696MOG-G-CCM
MBS692224-01Human CCM-1
MBS691545-01Human CCM-2
RWT-590MOG-G-CCM Cell Line
102-PA26Rabbit Anti-Human CCM-2
102-PA25Rabbit Anti-Human CCM-1
MBS9016204Rabbit anti-Caenorhabditis elegans ccm-3 Polyclonal Antibody

Popular Products