BMP-13 (GDF6) Recombinant Protein

BMP-13 (GDF6) Recombinant Protein

• Description: BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
• Synonyms: GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6
• CAS Number: 9000-83-3
• NCBI Gene ID: 392255
• UniProt: P43028
• Accession Number: NP_038554.1
• Accession Number mRNA: NM_013526.1
• Gene Location: 8q22.1
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Mouse, Human
• Sequence: TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
• Detection Range: The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: >95% by SDS-PAGE & HPLC analysis
• Length: 120
• Form: Lyophilized
• Molecular Weight: 27.0 kDa
• Shipping Conditions: Room Temperature