BDNF (Animal Free) Recombinant Protein
CAT:
209-100-005S-AF
Size:
2 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BDNF (Animal Free) Recombinant Protein
- Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
- Synonyms: BDNF
- NCBI Gene ID: 627
- UniProt: P23560
- Accession Number: NP_733931.1
- Accession Number mRNA: NM_170735.5
- Gene Location: 11p13
- Host: E. coli
- Origin Species: Human, Murine, Rat
- Species Reactivity: Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole
- Sequence: MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
- Detection Range: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
- Endotoxin: < 0.01 ng/µg of protein (<0.1EU/µg)
- Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
- Length: 119
- Form: Lyophilized
- Molecular Weight: 27.0 kDa
- Shipping Conditions: Room Temperature