Noggin (Animal Free) Recombinant Protein
CAT:
209-M10-124S-AF
Size:
5 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Noggin (Animal Free) Recombinant Protein
- Description: Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.
- Synonyms: Nog
- NCBI Gene ID: 18121
- UniProt: P97466
- Accession Number: NP_032737
- Accession Number mRNA: NM_008711
- Gene Location: 11 C; 11 50.5 cM
- Host: E. coli
- Origin Species: Mouse
- Species Reactivity: Mouse, Human, Chicken
- Sequence: MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
- Detection Range: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin.
- Endotoxin: < 0.01 ng/ug of protein (< 0.1 EU/ug)
- Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
- Length: 206
- Form: Lyophilized
- Molecular Weight: 46.4 kDa
- Shipping Conditions: Room Temperature