BD-1 (47aa)

CAT: 0209-100-133Size: 20 µgDry Ice: NoHazardous: No
CAT#:0209-100-133Size:20 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The Beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.
Synonyms
DEFB1; BD1; HBD1; DEFB-1; DEFB101
NCBI Gene ID
1672
UniProt
P60022
Accession Number
NP_5209.1
Accession Number mRNA
NM_005218
Chromosomal Location
8p23.1
Reactivity
Human
Cross Reactivity
Human
Sequence
GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100-1000 ng/ml.
Length
47
Form
Lyophilized
Molecular Weight
5.0 kDa
Host or Source
E. coli

Related Products

CatalogName
M10-244SBD-1
M10-244BD-1
M10-244-L100BD-1
M10-244-L250BD-1
M10-244-L500BD-1
M10-244-L1000BD-1
102-P219BD-1
100-132SBD-1 (36aa)
100-132-L250BD-1 (36aa)
100-132-L1000BD-1 (36aa)

Alternative Products

CatalogName
MBS691748-01Human BD-1 (47aa)
MBS650831-01BD1, Recombinant, Human, 47aa (beta Defensin-1)
B0900-05-01BD1, Recombinant, Human, 47aa (beta Defensin-1) discontinued
BITP2071-01BD-1
OM297038-01BD 1 Mouse
RC260-12BD-1, rat
HY-169130Lyso BD-1
Z02754-25BD-1, Human
OM297036-01BD 1 Rat
HC66601Human BD-1

Popular Products