BCA-1

• Description:

  BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant murine BLC is a 9.8 kDa protein containing 88 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

• Synonyms:

  Cxcl13; BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik

• NCBI Gene ID:

  55985

• UniProt:

  O55038

• Accession Number:

  NP_061354.1

• Accession Number mRNA:

  NM_018866.2

• Chromosomal Location:

  5 E3; 5

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Leech, Bacteria

• Sequence:

  VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml.

• Length:

  87

• Form:

  Lyophilized

• Molecular Weight:

  10.3 kDa

• Host or Source:

  E. coli