Apo-SAA

• Description:

  Human Apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL) . The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL Apolipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human Apo-SAA1alpha except for the presence of an N-terminal methionine and substitution of asparagine for aspartic acid at position 60 and arginine for histidine at position 71 (the last two substituted residues are present in apo-SAA2beta) .

• Synonyms:

  Apo-SAA

• NCBI Gene ID:

  6288

• UniProt:

  P0DJI8

• Accession Number:

  NP_000322.2

• Accession Number mRNA:

  NM_000331.4

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS NARENIQRFF GRGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 μM.

• Length:

  104

• Form:

  Lyophilized

• Molecular Weight:

  ~11.4 kDa

• Host or Source:

  E. coli