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Activin-A

CAT: 0209-100-012Size: 10 µgDry Ice: NoHazardous: No
CAT#:0209-100-012Size:10 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.
Synonyms
Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone) -releasing protein
NCBI Gene ID
3624
UniProt
P08476
Accession Number
NP_002183.1
Accession Number mRNA
NM_002192.2
Chromosomal Location
7p15-p13
Reactivity
Human/Mouse/Rat
Cross Reactivity
Human, Mouse, Rat
Sequence
GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Length
116
Form
Lyophilized
Molecular Weight
26.0 kDa
Host or Source
CHO cells

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