Activin-A

• Description :

  Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.

• Synonyms :

  Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone) -releasing protein

• NCBI Gene ID :

  3624

• UniProt :

  P08476

• Accession Number :

  NP_002183.1

• Accession Number mRNA :

  NM_002192.2

• Chromosomal Location :

  7p15-p13

• Reactivity :

  Human/Mouse/Rat

• Cross Reactivity :

  Human, Mouse, Rat

• Sequence :

  GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

• Length :

  116

• Form :

  Lyophilized

• Molecular Weight :

  26.0 kDa

• Host or Source :

  CHO cells